![]() ![]() These findings are consistent with preclinical data highlighting links between stress and anhedonia, and offer promising insights into potential mechanisms linking stress to depression. Additionally, PSS scores predicted reduced reward responsiveness even after controlling for general distress and anxiety symptoms. In both Study 1 (n=88) and Study 2 (n=80), participants with high PSS scores displayed blunted reward responsiveness and reported elevated anhedonic symptoms. Decreased reward responsiveness (i.e., the participants' propensity to modulate behavior as a function of reward) was used as an operational measure of hedonic capacity. Hedonic capacity was objectively assessed using a signal-detection task based on a differential reinforcement schedule. The Perceived Stress Scale (PSS) measured the degree to which participants appraised their daily life as unpredictable, uncontrollable, and overwhelming. As an initial step towards better understanding the association between stress and anhedonia, the present study tested, in two independent samples, whether individuals reporting elevated stress exhibit decreased hedonic capacity. This review will focus on factors that influence the function of. Activation of the hypothalamic-pituitary-adrenal (HPA) axis as a result of stress or other causes of arousal initiates a flood of hormone and neurotransmitter release throughout the brain, affecting the way we think, decide, and behave. ![]() Preclinical studies suggest that stress exerts depressogenic effects by impairing hedonic capacity in humans, however, the precise mechanisms linking stress and depression are largely unknown. The mechanisms and neural circuits that drive emotion and cognition are inextricably linked. ![]()
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